caspase 9 inhibitor z lehd fmk (R&D Systems)
R&D Systems is a verified supplier 
R&D Systems manufactures this product 
95
Structured Review
R&D Systems
caspase 9 inhibitor z lehd fmk
Caspase 9 Inhibitor Z Lehd Fmk, supplied by R&D Systems, used in various techniques. Bioz Stars score: 95/100, based on 337 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/caspase+9+inhibitor+z+lehd+fmk/Caspase-9+Inhibitor+Z-LEHD-FMK/bio_rxiv__64898__2026__03__13__711679-142-0-4
Average 95 stars, based on 337 article reviews
Caspase 9 Inhibitor Z Lehd Fmk, supplied by R&D Systems, used in various techniques. Bioz Stars score: 95/100, based on 337 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/caspase+9+inhibitor+z+lehd+fmk/Caspase-9+Inhibitor+Z-LEHD-FMK/bio_rxiv__64898__2026__03__13__711679-142-0-4
Average 95 stars, based on 337 article reviews
caspase 9 inhibitor z lehd fmk - by Bioz Stars,
2026-09
95/100 stars
Images
1) Product Images from "Energy Flux Regulates Cell Death Induced by California Serogroup Orthobunyaviruses"
Article Title: Energy Flux Regulates Cell Death Induced by California Serogroup Orthobunyaviruses
Journal: bioRxiv
doi: 10.64898/2026.03.13.711679
Figure Legend Snippet: (A-B) BE(2)-C wild type cells were treated with nothing, DMSO vehicle, or 5 µM oligomycin ATP synthase inhibitor immediately prior to inoculation with LACV (MOI = 1) or INKV (MOI = 1). At 48 (LACV) or 96 (INKV) HPI, the percent survival was determined as compared to uninfected controls. (C) BE(2)-C WT cells were treated with nothing, DMSO vehicle, or 10 µM Z-LEHD-FMK caspase 9 inhibitor immediately prior to inoculation with LACV (MOI = 1). At 48 (LACV) HPI, the percent survival was determined as compared to uninfected controls. (D) BE(2)-C WT cells were treated with nothing, DMSO vehicle, or 10 µM Q-VD-Oph pan caspase inhibitor immediately prior to inoculation with LACV (MOI = 1). At 48 (LACV) HPI, the percent survival was determined as compared to uninfected controls. (A-D) Asterisks represent significance values from one-way ANOVA as follows: *p ≤0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001; n = 3.
Techniques Used:
Figure Legend Snippet: (A&D) The effect of interventions on apoptosis was interrogated by measuring activated caspase 9 approximately 24 hours post treatment via flow cytometry. Camptothecin (4 ug/mL) was utilized to induce apoptosis via caspase 9 action. Activated caspase 9 was detected using a fluorochrome inhibiter of caspases (FLICA) conjugated to a green FAM fluorescent probe. Samples were run on a CytoFLEX LX cytometer and the percent change in median fluorescence intensity (MFI) from BE(2)-C wild type, untreated cells was reported. (A) 10 µM Q-VD-Oph pan caspase inhibitor was challenged with LACV MOI = 1 or camptothecin (4 ug/mL). Each bar represents the MFI from a single run of flow cytometry; traces are available in Supplemental Figure 6. (B) BE(2)-C wild type cells were treated with DMSO vehicle or 10 µM Q-VD-Oph pan caspase inhibitor immediately prior to inoculation with LACV (MOI = 1, 5) then incubated at either 37°C or at 33°C for 48 HPI. Percent survival was determined as compared to uninfected controls. (C) BE(2)-C wild type cells were pre-grown for at least three days and subsequently maintained in media with either 10 mM galactose or 10 mM glucose as the primary carbon source. Cells were treated with either DMSO vehicle or 10 µM Q-VD-Oph pan caspase inhibitor immediately prior to inoculation with LACV (MOI = 1, 5). At 48 HPI, percent survival was determined as compared to uninfected controls. (B-C) Asterisks represent significance values from unpaired t-tests as follows: ns = not significant, *p ≤0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001; n=3. (D) 10 mM galactose as the primary carbon source (initiated at least 3 days prior to and maintained through inoculation and incubation), 5 µM oligomycin, and 33°C incubation temperature were challenged with camptothecin (4 ug/mL). Each bar represents the MFI from a single run of flow cytometry; traces are available in Supplemental Figure 6.
Techniques Used: Flow Cytometry, Cytometry, Fluorescence, Incubation
Related Articles
Activity Assay:Article Title: Synthetic cannabinoid CP-55,940 induces apoptosis in a human skeletal muscle model via regulation of CB 1 receptors and L-type Ca 2+ channels. Article Snippet: Rhabdomyolysis has been reported in patients who abuse synthetic cannabinoids.. However, no studies have yet assessed whether these cases reflect the direct cytotoxicity of synthetic cannabinoids on skeletal muscle, a possibility that the present study sought to address.. Specifically, this study investigated the cytotoxicity of the synthetic cannabinoid CP-55,940, a compound that acts equally on both types of cannabinoid receptors (CB1 and CB2), in a human embryonic rhabdomyosarcoma (RD) cell line. Incubation:Article Title: Synthetic cannabinoid CP-55,940 induces apoptosis in a human skeletal muscle model via regulation of CB 1 receptors and L-type Ca 2+ channels. Article Snippet: Rhabdomyolysis has been reported in patients who abuse synthetic cannabinoids.. However, no studies have yet assessed whether these cases reflect the direct cytotoxicity of synthetic cannabinoids on skeletal muscle, a possibility that the present study sought to address.. Specifically, this study investigated the cytotoxicity of the synthetic cannabinoid CP-55,940, a compound that acts equally on both types of cannabinoid receptors (CB1 and CB2), in a human embryonic rhabdomyosarcoma (RD) cell line. Article Title: Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts. Article Snippet: .. For caspase inhibition, fibroblasts were incubated with 20 μM pan caspase inhibitor Z-VAD-FMK, 20 μM caspase-8 inhibitor Z‐IETD‐FMK, 20 μM Inhibition:Article Title: Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts. Article Snippet: .. For caspase inhibition, fibroblasts were incubated with 20 μM pan caspase inhibitor Z-VAD-FMK, 20 μM caspase-8 inhibitor Z‐IETD‐FMK, 20 μM Article Title: Caspase Inhibition Affects the Expression of Autophagy-Related Molecules in Chondrocytes. Article Snippet: Micromass cultures were utilized as a common in vitro method to investigate chondrogenesis.29 Cells were obtained from mouse fore limbs at E12 by a standard protocol30 and left until the following morning in order to attach to the surface. .. For caspase inhibition, pharmacological inhibitors: Pan Caspase Inhibitor Z-VAD-FMK, Caspase-2 Inhibitor Z-VDVAD-FMK, Caspase-3 Inhibitor Z-DEVD-FMK, Caspase-6 Inhibitor Z-VEID-FMK, Caspase-8 Inhibitor Z-IETD-FMK, other:Article Title: Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity Article Snippet: The caspase-8 inhibitor z-IETD-fmk and the Article Title: Protective roles of cytoplasmic p21 Cip1 /Waf1 in senolysis and ferroptosis of lung cancer cells Article Snippet: The pan‐caspase inhibitor z‐VAD‐FMK was purchased from Enzo Life Sciences, and both caspase‐8 inhibitor z‐IETD‐FMK and Concentration Assay:Article Title: Caspase Inhibition Affects the Expression of Autophagy-Related Molecules in Chondrocytes. Article Snippet: Micromass cultures were utilized as a common in vitro method to investigate chondrogenesis.29 Cells were obtained from mouse fore limbs at E12 by a standard protocol30 and left until the following morning in order to attach to the surface. .. For caspase inhibition, pharmacological inhibitors: Pan Caspase Inhibitor Z-VAD-FMK, Caspase-2 Inhibitor Z-VDVAD-FMK, Caspase-3 Inhibitor Z-DEVD-FMK, Caspase-6 Inhibitor Z-VEID-FMK, Caspase-8 Inhibitor Z-IETD-FMK, Control:Article Title: Caspase Inhibition Affects the Expression of Autophagy-Related Molecules in Chondrocytes. Article Snippet: Micromass cultures were utilized as a common in vitro method to investigate chondrogenesis.29 Cells were obtained from mouse fore limbs at E12 by a standard protocol30 and left until the following morning in order to attach to the surface. .. For caspase inhibition, pharmacological inhibitors: Pan Caspase Inhibitor Z-VAD-FMK, Caspase-2 Inhibitor Z-VDVAD-FMK, Caspase-3 Inhibitor Z-DEVD-FMK, Caspase-6 Inhibitor Z-VEID-FMK, Caspase-8 Inhibitor Z-IETD-FMK, |